I too have been injecting myself, in my case with Interferon for Polycythemia Vera. I inject only into the belly and have no pain, not ANY pain (well, a faint sting). However, the INF is giving me very bad neuropathy in my feet. about 10 hours after the shot, three times a week, the blow torch on my toes starts and goes on for hours. Demerol has not been enough to stop it in the moderate dose I consider OK, so I am taking Tylenol, which is a risk because I have Porphyria too. This is awful. Worst misery of my life, I think, but of course we do forget the horrors we went through, like the neurological impairments I had leading up to MS diagnosis. But for sheer pain, this is as
bad as Shingles, and harder to mollify. I am thinking I may not continue.

Muscle for sure, and what Dej said about avoiding injecting the tops of the thighs, oh yes. I hit a muscle there once and never again (because I switched to the sides). I found myself in the same state, leg in severe pain, difficult to walk, lasted several hours. It was dreadful!

I had the exact same problem with the tops of the thighs. The nurse at my neuro's office suggested I use the sides so now I rotate around using both the insides and outsides of the thighs. I also adjusted the depth on the auto-inject so I'm going a tad deeper - that seems to help with the big lumps that used to appear. I wish I could inject in my stomach every day - that's the easiest area...sounds like it's true for other people as well. It's all trial and error really...this summer I will have been on C for 2 yrs...it does get better. I'm really hoping my MRIs look good so I can stay on it - I've been tolerating it very well and I really don't want to mess around with the side effects of the other drugs...Good luck everyone!