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Old 02-23-2011, 06:31 AM #23
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
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The headache complaint from aspartame has been around for a LONG time. It affects many people. I think it is real.

Aspartic acid is a neuroexcitatory amino acid. It and glutamate, both stimulate NMDA receptors which are pain receptors.
http://en.wikipedia.org/wiki/N-Methyl-D-aspartic_acid

http://www.medscape.org/viewarticle/567856
This is an excellent paper and if you don't belong to Medscape, you can join for free easily. It is worth it for this paper.

Magnesium is an antagonist to the NMDA receptor. That is why fixing low magnesium levels improves pain for many people.
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