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Old 06-04-2015, 08:28 AM #11
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Originally Posted by caroline2 View Post
I know that OPC's address Edema. I'm headed into my 20th year of taking Pycnogenol first in the beginning year and then finding grape seed extract just as effective and less money. I've had 2 bouts of edema, one from BP med and the other after hip replacement surgery and upping my grape seed extract for a while knocked out the edema. I have a post in the vitamin/supp section here.

One on pharma blood thinner cannot take both.
Taking Grape Seed Extract is in my opinion a VERY VERY VERY BAD idea if one has MS.

Here is the reason MS folks should avoid GRAPE SEED EXTRACT.

Increased Interferon Gamma is VERY VERY BAD for MS folks. When they first discovered it they gave it to 10 MS folks to see if it would help them. They ALL got MUCH MUCH WORSE!

jackD

p.s. Grape SKIN EXTRACT is GREAT for MS folks. We do need some Gamma Interferon for a healthy immune system and to even repair our damaged nervous system.



Clin Diagn Lab Immunol. 2002 Mar;9(2):470-6.

Quote:
Grape seed extract activates Th1 cells in vitro.

Nair N, Mahajan S, Chawda R, Kandaswami C, Shanahan TC, Schwartz SA.


Source

Division of Allergy, Immunology, and Rheumatology, Department of Medicine, State University of New York at Buffalo and Kaleida Health, 14203, USA.


Abstract

Although flavonoids manifest a diverse range of biological activities, including antitumor and antiviral effects, the molecular mechanisms underlying these activities await elucidation.

We hypothesize that the flavonoid constituents of a proprietary grape seed extract (GSE) that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-gamma) by peripheral blood mononuclear cells) from healthy donors.

Our results show that GSE significantly induced the transcription of IFN-gamma mRNA as demonstrated by reverse transcription-PCR but had no effect on the Th2-derived cytokine interleukin-6. The enhancing effect of GSE on IFN-gamma expression was further supported by a concomitant increase in the number of cells with intracytoplasmic IFN-gamma as well as the synthesis and secretion of IFN-gamma.

Our results demonstrate that the potentially beneficial immunostimulatory effects of GSE may be mediated through the induction of IFN-gamma.

PMID: 11874895 [PubMed - indexed for MEDLINE]
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Old 06-04-2015, 09:27 AM #12
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Thanks jack, I was going to make a similar point but you beat me to it . Though I will throw in that the most beneficial "OPCs" of grapes is found in the skin, not the seeds. More WINE FOR EVERYONE!!!
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Old 06-14-2015, 05:18 PM #13
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More WINE FOR EVERYONE!!!
Oh Starznight, you always say the right thing!
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Old 06-14-2015, 05:34 PM #14
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Interesting info, grape skins OK but not the seeds. I never did this research but I don't deal with MS, my sister does and don't think she ever got on grape seed ex.
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Old 06-14-2015, 06:35 PM #15
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Originally Posted by jackD View Post
Taking Grape Seed Extract is in my opinion a VERY VERY VERY BAD idea if one has MS.

Here is the reason MS folks should avoid GRAPE SEED EXTRACT.

Increased Interferon Gamma is VERY VERY BAD for MS folks. When they first discovered it they gave it to 10 MS folks to see if it would help them. They ALL got MUCH MUCH WORSE!

jackD

p.s. Grape SKIN EXTRACT is GREAT for MS folks. We do need some Gamma Interferon for a healthy immune system and to even repair our damaged nervous system.



Clin Diagn Lab Immunol. 2002 Mar;9(2):470-6.


Thanks for clearing that up, Jack. Not all supplements are safe for everyone. Everyone should do their own research before beginning anything.
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