What Larry and HereKitty say is true for some LDNers. Not all get a lot of symptom relief...I only had a little, because I was SPMS, when I started.

The one thing I had, from the very beginning was a feeling of well being. I thought it was just the placibo effect but, it never went away. I must have needed that raise in endorphins.

The important thing, to me, is that, except for an occasional stress or heat related flare, I have had no lasting exacerbations and very little progression of disability..(my growing older is what adds more to my disability than the MS.

I would say a good try time for LDN is probably 6 months to a year. I can't tell you how many times I threatened to quit LDN, in that first year but, everyone encouraged me to stay the course....and I am so glad I did. It didn't stop my MS and only gave me some symptom relief but taking it made me feel better.

I did have better stamina, balance, clarity of mind, when clsing my eyes in the shower, I didn't get dizzy and fall anymore and I had better bladder and bowel control.

I'll tell you what I was told.......Stay on, at least 3mg, stay the course and things will slowly get better. Maybe I talked myself into it, but that seems to have been the case for me.

I suppose there are those of you who may be allergic to Naltrexone or the filler or both and some of you may be more susceptable to the SX such as stiffness and insomnia. If you are allergic, then stop, but if you can make it through the first week or two of SX, then stay on the 3mg and later, try the 4.5mg.

Some of you sound just like I did, at first. I expected too much and saw the wonders it was doing for some others, like Larry ( we started LDN at about the same time and while I was struggling, he was seeing great sx relief and success). I believe the difference is, that he was RRMS and I was SPMS, and a few thousand years older.

LDN still works for me, in the way it should, so I'm on it for life.

Good Luck and Love to You All.