Hey Sally. I know how it suppose to trick the body into saying "hey..i dont have enough so produce more"
Tell me why you don't believe it would work in the situation I described? Curious.

Spoke with the leader from MS group just now on phone. Regarding other issues but when we were hanging up she said well..I sure learned alot!
Taught her testosterone, esters, dermatomes (surprised she didnt know derms) ect. Job well done.

What Sally said is exactly how it works. It is not to keep you up, like a anti-fatigue medication. And it does not make endorphins at will.

Only when our body starts making endorphins on it's own, at night, it blocks them, then the body thinks it needs more, so when the blocking ends, we have many increased endorphins. At that time, most feel it starts helping with pain because of the endorphin rush and energy by morning.

It is not an upper pill, or energy booster to take during the day. Read the LDN website again Eddie, it might help. I re-read it often. I have a lot to learn myself.

I stopped taking it (wasnt religiously anway) because I couldnt sleep at the most important time of night and I actually lost some sensory when I couldnt sleep. I still have it and next time I try it will be preworkout because if its true exercise increases endorphines, someone explain why before you say no it won't work.

I am really surprised to hear this. You looked so hard to find a neuro that would prescribe it and then didn't even take it correctly or for the 6-12 months to see desired results???

Not that there is any guarantee that LDN would work for you....but just that you didn't try.

The research is to take the LDN at night between 9pm and 3am. Maybe someday someone will do a research on LDN and preworkout....but for now there is no research in that area.

Hi Eddie,

I'm gonna give this a try! We aren't taking LDN to suppress our endorphin production but to INCREASE it. We produce the most endorphins after 3:00 am. We take LDN before that time to decrease the production so that later, when our body naturally puts out more enodrphins, it will realize it is short and make a whole lot more.

When you exercise, you produce more endorphins, so it makes no sense to me to take LDN and put a damper on that. You're doing naturally what we're trying to do with LDN. I think that the exercise is a great complement to LDN when you take it at night.

If you take LDN on a hit and miss basis, you're probably not letting your body adjust to it's mechanism of action and that's most likely the reason for your sleep problems.

I hope you can figure out a way to make it work for you. I take mine when I go to bed so I'm already asleep before it kicks in anyway. Just ridding me of the heat intolerance made it invaluable to me. Everything else was just a perk.

C

The main reason why I didnt take it every night was because i couldnt sleep. Ive been keeping my testosterone level high and that will do it (sleeplessness). So therefore by waking up at 4am and twisting turning actually Hurt my E production (i think).

As far as studies go, I surely don't need one to try something Just makes me wonder why if blocking E at night causing the brain to say hey! I didnt make enough so make more!..WHY then wouldnt the brain do the SAME thing during a workout if it produces it for who knows what reason but it does and therefore should say hey! I need more!

I told Dr yesterday I don't think it's the magic bullet for me but..Happy Happy joy joy! he gave me what my last neuro dumped me for cause I asked for it every appt. I believe it will help me and been wanting to try it for almost a yr now. I just have to monitor my cd4+ cell level. Lowering it is a good thing..lowering it too much is a PML risk. Yes I'm on Ty and armed with info so going to roll with it. If the neuro that dumped me didnt put me on Ty I wouldve stayed on Copaxone and took a chemo drug that starts Na?...I forget. Worked on lady at MS group. Put her in total remission. 2 yrs is max though. Still working a couple yrs after. Back to ldn

Eddie, good luck with the Ty. I hope it works for you. I guess you know about the Ty Sticky on here for those that are on Tysabri. Aren't you starting Ampyra too soon? Best wishes.

The na is probably Navatrone, a cancer chemo drug. Kinda scarey side effects.

Good wishes with watever you try.

I'd give LDN another try. It caused sleeplessness for me, too, but I toughed it out and it went away. I'd definitely try it again before taking anything like Ty or Novatrone.

I tend to go to bed kinda early anyway and always wake up between 12-1 AM so I just take my LDN whenever I wake up. Sometimes it's closer to 2-3 AM but that's even better!

Ok, I'm going to call a doctor from one of the online lists to see if I can get some LDN.

Any suggestions on one to call?

There arent any in Nebraska that I can find, so I'm just going to close my eyes and put my finger on the monitor (if I can find it with my eyes closed) and see what name on the list I have my finger is closer to.

Hopefully it wont be too horribly expensive. I dont know if I'd be calling the ones that say they charge $500 for the first consult.

What do I say when I call?

I hope I can get a Rx and I really hope it works for me. (not expecting it to, but hoping!)