[Stellatum]

I read in this excellent overview:

http://www.uwo.ca/cns/resident/pocke...uscular/MG.pdf

...that if Mestinon is not effective for a patient, it might be because a certain kind of binding antibodies result in the destruction of the muscle endplate (see the end of page four and beginning of page five). The resulting loss of aceytylcholine receptors is describes as "more long-lasting" than, for example, when the receptors are just temporarily blocked by antibodies. How long-lasting is long-lasting?

What I would really like to know is this: if a patient had those sorts of antibodies, would his MG symptoms not fluctuate? Because mine sure do. I'm strong in the morning and I get weaker as the day goes on. I also have stronger days and weak days, and also less weak weeks and much weaker weeks. My muscle weakness also moves around--six months ago I was having trouble swallowing, and now I'm not, for example.

I'm trying to find an explanation for why Mestinon doesn't do me any good. Since I'm seronegative, the fact that Mestinon doesn't help (and that my eyes are still fine) is one more doubtful factor in my mind, especially as I near the end of the 10 months that's supposed to be the longest you have to wait for Imuran to start working.

Abby