Hi Paula and others, My internet service and telephone have been out for a few days. I was almost done responding when I got kicked off, I'm not blowing you off. Since my c-sections,(1977,1980), I've had other surgeries where they used something different. They were aware of the deficiency. With insecticide, I wheeze,cough,etc. and was always told I had asthma.I also had my children tested. Luckily,they are fine.I have heard that I shouldn't take muscle relaxers either. Thanks for exploring this topic. You are all so curious and smart. Happy days! Fran

Here's another quick reply that;s not very quick. I take mirapex for PD. It works well for my symptoms but I have gained 40 pounds. I also had major depression and took effexor which made my blood pressure go way up and caused a retinal occlusion. (I always had low BP) Now I'm on cymbalta among other drugs. Paula, you mentioned pamalor(nortrip). I was on pamalor for 10 years for migraines. It was a miracle drug for me. I never realized that people felt so good,until I started taking pamalor. I was able to get the dose down to 10mg/day and that is when my foot started with the tremor.4/05. I wonder if the pamalor held back the PD for a few years? Cheers! Fran

Hi franny,

That was another helpful piece of information! If you felt good on pamelor, you must be getting one of its intended purposes...regulation of acetylcholine. In this case, it is enabling the enzyme that breaks it down; so your cholinesterase dysfunction is translated into too much acetylcholine?? with parkinson's, it would respond well to the regulating of it and keeping it lower that nortiptyline enables, because now you also lack dopamine.

Complete speculation, but I think the questions are reasonable. keep in touch if you can franny....thank you for sharing your information. It's new to me.

Hello, I was diagnosed with this back in 1987 when I was 27 and had an emergency surgery for an ovarian cyst. Not only was I on a respirator but they had to restart my heart many many times as it paralyzed my heart muscle too. I was told they used anectine. Was told normal was (8-18) and I was 1.5

Your experience is frightening. I wonder how many docters even know about this. Is there a way to test for it in advance other than genetic analysis? This is one reason sham surgery is dangerous.

Thanks for sharing it!
paula

Hi There.

I have been researching the effects of pesticides combined with enzymes, as i have mulitple chemcial sensitivity. Some researchers say that a lack of the P450 enzyme contributes to the intollerance of processing chemicals. What bought me here to post was my research on permethrin and health effects, to which there are many and to answer the query is it linked to parkinsons etc. Yes it is.
Permethrin exposure has been linked to both Parkinson’s disease and Gulf War illness (Plapp Jr FW 1999, Karen DJ et al 2001).

There is a good link with all the facts in one place - good reading but i cant post links yet apparantly *edit*

Dianne

Hi ecohealth,

Glad to have u join us,

Holler if u need more help.

Hi, I have just joined whilst searching web on pseudocholinesterase defiency. I have known I have this sice having an emergency c section 12 years ago with my son. I came round from the aneasethic but found i was paralised unable to breath, thankfully the nurses heard me choking and I was put on a ventilator etc. I don't remenber much more than listening to the panic in the recovery ward, my body went into shock. I didn't see my new baby son until the following morning.... The experience has left me afraid of surgery. No one else in my family has tested positive for it.
I have recently been unwell with chest pains and such, had an ecg which was significantly abnormal. I've been into hospital but am awaiting more tests, hence I thought I should do my own research. I also have Protein C deficiency so I am just on my research path. It's surprising here in the UK how little doctors know about these things. I seem to spend alot of time explaining what I have and what it means.... more surprisingly is that they rely on what I tell them....The more I learn the more concerned I become. I am sure there is a link between the deficiencies and my current poor health. If anyone can shed any light would be very grateful

*admin edit*

Choline aka acetylcholine is crucial for brain health and many people are deficient in it. It may well be those with Parkinson have too much but a deficiency has been linked to dementia among other things. That is why Aricept and other drugs for dementia contain it. There was an article in medscape recently which definitely reports on a link between a plethora of drugs known as anti cholinergics.

**some people acquire it from certain drug interactions or liver disease, but it is often genetic. Very rare in certain populations like 1 in 5,000 but as many as 1 in 10 of Persian (Iraqi) Jews and Indian populations.

and this "do people with pseudocholinesterase deficiency have cognition exceptionalities of any kind?" Some research they might be more prone to Alzheimers but not conclusive.

"what happens if you don't know you have it is you stop breathing and have trouble waking after surgery. this is because you have a mega acetylcholine type drug, along with dsyfunctional enzymes that do not break it down. So another enzyme is breaking it down but slower -so you don't wake up for a longer period of time. muscles are paralyzed. but they have the machines to bring you back...unless you are a kid.....then you can easily die. Thus the warning." ....Unless you are a kid? Why cannot kids be monitored and put on a breathing machine? ** People are advised to wear medic alert bracelets for this.- it can kill people if the doctors are not aware and prepared to intubate a patient asap (Joan Rivers? She may not have had this but doctors were not prepared to intubate her and had problems). I find it especially scary re all these ambulatory clinics with lax measures for emergencies. And if you cannot breathe on your own it is an emergency.

As well these people have a higher risk of cardiac arrest from cocaine use...and local anesthesia can cause illness as well....dentists and all others who plan to use a local for whatever reason need to be informed of this condition.

I understand it is all fascinating stuff but we need to use caution when we do our ** research and then make assumptions that are wrong and announce them in public settings as if they are fact.

It is a very confusing topic. I recently realized I tested for it (via 23andme). Always had trouble with anesthesia, so does my sister coming out of it. And we have only one dna marker for it. If we had two it would e a more extreme reaction (sometimes paralyzed for hours!) Recently had a root canal and after I told the dentist I had a heart condition he used a local that paradoxically was a choline ester. I almost fainted and was out of sorts for a few hours. Dentists usually cannot hurt us too much unless they really use a lot. My father did not come out of a twilight for a kidney stone smashing procedure for hours (which makes me think he had two markers), my grandfather, his father had Parkinsons. So interesting stuff still a lot of questions.