Wondering if anyone here has tried a Medicinal Marijuana regimen? At this point I'm willing to give it a try, but I live in IN--where we always tend to wait ten years before trying anything "new"...as if marijuana were new.
Many thanks.

Hello and welcome to Neuro talk. There is a whole thread about this issue. MM is being used now for many different kinds of disorders. I am going the legal route in trying to get the law passed in my state. On the search bar just type in Medical M. I wish you all the best. ginnie

Since there are little more than "unconfirmed" reports of the benefit of MM in PD , i suggest that we all try it and come up with a verdict of just how helpful MM is in PD. I have tried it, and had considerable success with calming dyskinesia, and found that it can be the only thing that works for depression, much better than SSRI's and the like. But that is me, i am sure that it's not for everyone of us (getting "stoned" is not for everyone!) There are also anecdotal reports that the antidyskinetic and antiseizure principle is cannabidiol, which is apparently not psychoactive, and may be useful by itself. If used properly i think it has a useful role to play in PD therapy. But it still doesn't do anything to make one feel "asymptomatic", so, is probably just another palliative agent. But if it works dont try to fix it!
I tried to find anything on the web about cannabinoids being excitatory amino acid antagonists, but no real hits.

Yes the thing is, it does work for many people. I have PN and had a window of opportunity last year to try it. There was a noticeable difference, so I joined the campaign to get it on the ballot. In my opinion a grown adult should try what ever he can to help symptoms and live a better life. It is about quality of life. I don't care if it is all in the head, I really don't, if it helps suffering, it is worth the try. ginnie

cannabidiol excitatory amino acid antagonist

cannabis parkinson’s disease and the endocannabinoid system

Doc

Post this and pique my curiosity and get my neuroscience, up to a semi-understanding again, wouldn't you, when i just want to forget about that complex can of worms! Many of the papers and references i read and see that at least some researchers are delving into receptor modulation, in an attempt to determine the effects of the endogenous ligand anandamide, or the partial CB1 and/ or CB2 partial agonists, The cannabinoids , and what effects could be modulated by looking at interaction with excitatory amino acid agonists and antagonists, but most of it was studies on the striatal dopaminergic
system. The motor effects of cannabis agonists/antagonists are a different story (i think). I also think that both dopaminergic compartments in the brain use the endogenous ligand, and it's natural mimics, exerting different effects down the g-protein cascade. I am not by any means familiar with the work that has been done lately in neurochemistry, that would allow me to make an educated guess exactly what cannabinoids do in different brains, and also why some people react to cannabinoids so differently. This is kind of a mystery (not just the psychological effects, but the pain relief, and anticonvulsant/ antiseizure, antiemetic, and other physiological effects. That aside, all i have to say is that every parky should at least try it and we can build a picture of its true usefulness (or not) in PD.And last but not least my thoughts could be about as useful as a lump of coal nowadays.

Thank you for the information. All we can do is post the latest information and hope for the best. In a nut shell, you are talking about almost all medications. It is the same with every drug. Every person reacts differently. I cannot take Lyrica, or Gaba, and other people do just fine on it. I think it will be the same with the CDB's and THC. Some will benefit from it, others will not. The point is, we should be allowed to try this when other therapies have failed, or are not as effective. As I have stated before, I don't care how it works, just so long as it does help people. Mental, physical or emotional, if this works to help suffering, it is worth the effort in this country to get in into main stream medicine. It works for my PN and I am not in a state that allows it. So I joined up to get the vote out in Nov. I will move if I have to, if this state fails to pass it. ginnie

If I'm reading you correctly, I think it has to do with the fact that in whole-plant MMJ, there are literally hundreds of cannabioids—only 2 of which we know much about—and the effects have as much to do with combinations and ratios as with dosage.

We've lost ~80 years of research time due to racial prejudice, ignorance, & politics.

Doc

I just found a very informative article by a PD neurologist about cannabis:
http://thepotbook.com/potbook/additi...amos-Final.pdf

Trixiedee

I'm not big on getting stoned so, the THC route isn't really for me however, I did try THC after watching a video showing great results on an older PD man. I was desperate and willing to try most anything. It did nothing for me. I then had dbs which helped with many issues. I did continue to have severe joint pain and sleep problems. I tried a topical called Sootheen Indicreme which was recommended to me by a doctor friend. It did wonders for my aches and pains. I started buying it online and while visiting their site I noticed that they make products that contain cannabidiol derived from
Hemp. So I got some of their liquid cbd and it has done wonders for several issues. I am now able to sleep through the night. It also seems to diminish joint pain. Less specifically it seems to generally help anxiety. Because it is hemp based it is legal and you can order it from any state.