1. I went to the neuro last week. He gave me the balance test (you know, trying to get you off balance). i have always done well, but fell twice this time. I am wonderingif I may have fullblown PD now (still don't have cogwheeling and stiffness, but seem to have all other sx that I remember).

2. I have been recovering very slowly from surgery. I was only sleeping 1-5 hrs per night of broken sleep. He is having me tested for narcolepsy, but gave me remeron to take at bedtime. (He also rescinded my permission to drive).

He left the room to check for drug interractions; returned and said that there were no problems. I have been taking it since Thursday. The half life is 37 hours. Each day I am more tired and weaker. I checked and found a moderate interaction between remeron and mirapex involvin CNS and Resp. system.

Yesterday I went on a walk of about 400 feet. It took me about half an hour to get back. By the last 200 feet or so I was only moving my feet 3 or 4 inches, I was to tired to keep my eyes open, and my head drooped.

Last night I had problems breathing when I went to bed.

The neuro's nurse told me to quit taking the remeron for tonight and that she would ask the dr tomorrow.

Questions
1. What are the c hances that I have full blown PD instead of parkinsonism?
2. Has anyone else had a reaction between remeron and mirapex

Thanks,

I don't have answers just bumping it up.

paula

mama, do you see a general practice neurologist or a movement disorder specialist? Is this the only neurologist you have ever seen for your PD?

Have you discussed this possible medication interaction with a Pharmacist?
It is a pharmacist's job to help with drug interaction issues and to make suggestions for alternate medications your doctor can use.

I can see from your words how distressing your situation must be.

Hopefully someone has dealt with this issue and will reply here.

yes you are correct -mirapex and remeron do not mix -

Interactions between remeron (mirtazapine) and Mirapex (pramipexole)
mirtazapine and pramipexole (Moderate Drug-Drug)

MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

please call your pharmacist tell him to tell you about the breathing problems and she/ he will look it up, they may call your doctor for you if yoiu have scripts at the pharmacy... do call your doctor, or have a loved one call for you...


http://www.drugs.com/drug-interactio...ex_d04145.html

My doctor (neuro) finally called yesterday and apologized for any trouble that the drug caused. He told me to stay off it and that he would have me start elavil when I am feeling better. I have decided that I am going to work things through sans meds.

This isn't the only neuro I have been to, several years ago I saw one in Charlottesville and one in North Carolina. He is my local. He decided in Sept. that maybe this isn't all in my head and has decided that I have viral parkinsonism. Failing the balance test this time makes me think that perhaps he is wrong since he said that there would be no more progression with what I have.

Thank you so much for bumping this up and for answering. I was afraid that I had upset someone and that I was blacklisted or something as it went for quite awhile with no responses.

Thanks again,