Hypothyroid Neuropathy?

Stacy2012 · 12-09-2012, 07:57 PM

katycoyote,

Your story is pretty much my story. I too went to the site stopthethyroidmaddness.com and found it to be EXCEPTIONAL when it comes to information about thyroid.

I am on Nature-throid, the desicated meds. My TSH was a 10.8 and came down to a 2.5 (or near that i cant remember exact at this moment). I am so very happy I fought hard to use desicated thyroid meds. It came down like that and I am only on 1/2 grain (broken up to 2 times a day).

However, as you said, I still have neuropothy in my feet. However, the numb spot on the back of my heal is definately getting better, almost all feeling has returned. BUT I would rather have the numb spot than this horrid burning.

Benfotiamine helps me the most.

Idiopathic PN · 12-15-2012, 07:41 PM

Quote:

Originally Posted by mrsD

The problem with Cytomel is that is has a very very short half life in the body.

It might be possible to get it from a compounding pharmacy who will compound it into a sustained release form. You might have better results then without raising doses so high.

Also some compounding pharmacies have natural animal gland product as well.

So check your area to see if one can accommodate you this way.

T4 is converted with zinc and selenium. Being low on either one will reduce this conversion to T3 in tissues.

Mrs. D, I started on cytomel a week ago. Please clarify for me your statement : "compounding pharmacy who will compound it into a sustained release form ", does it mean a pharmacy will prepare the formula for you? Does this require a special prescription from a doctor?
Thank you.

mrsD · 12-16-2012, 05:39 AM

Yes, it would require a special prescription.

However, the way T3 works, it would only confer a small advantage. T3 is quickly absorbed into tissues. It is not protein bound and carried around for a longer time period like T4 is.

T4 is designed biologically thru evolution to be a "backup" and standby, as part of the biofeedback process.

Too much T3, will over stimulate tissues over time, and lead to side effects, like bone loss, and cardiac stimulation. Too much thyroid is a factor in osteoporosis.

A sustained release form of T3, would slow the absorption down a little each day. But it too is not perfect. I don't think any of our thyroid treatments are "perfect" yet.
http://www.drugs.com/pro/cytomel.html

Quote:

Since liothyronine sodium (T3) is not firmly bound to serum protein, it is readily available to body tissues. The onset of activity of liothyronine sodium is rapid, occurring within a few hours. Maximum pharmacologic response occurs within 2 or 3 days, providing early clinical response. The biological half-life is about 2-1/2 days.

T3 is almost totally absorbed, 95 percent in 4 hours. The hormones contained in the natural preparations are absorbed in a manner similar to the synthetic hormones.

Liothyronine sodium has a rapid cutoff of activity which permits quick dosage adjustment and facilitates control of the effects of overdosage, should they occur.

Stacy2012 · 12-16-2012, 10:26 AM

Have you tried desicated natural thyroid hormone??

In my opinion, it is the best option out there...thats just my opinion.

Idiopathic PN · 12-16-2012, 06:44 PM

Quote:

Originally Posted by mrsD

Yes, it would require a special prescription.

However, the way T3 works, it would only confer a small advantage. T3 is quickly absorbed into tissues. It is not protein bound and carried around for a longer time period like T4 is.

T4 is designed biologically thru evolution to be a "backup" and standby, as part of the biofeedback process.

Too much T3, will over stimulate tissues over time, and lead to side effects, like bone loss, and cardiac stimulation. Too much thyroid is a factor in osteoporosis.

A sustained release form of T3, would slow the absorption down a little each day. But it too is not perfect. I don't think any of our thyroid treatments are "perfect" yet.
http://www.drugs.com/pro/cytomel.html

Thank you MRs.D. I went to my local pharmacy, unfortunately, they do not do compounding.

My TSH has gone haywired. Never did my T3 has gone out of range, till recently even after the total thyroidectomy. I am not sure if this abnormality in my thyroid function is causing the flare ups of my neuropathy (if not the usual pain cannot be considered as flare-ups).

I am interested to know if the TSH, T3 and T4 are back to the normal levels, can I go back to just taking Synthroid without Cytomel? I am trying to minimize my medications to protect the liver/kidney.

mrsD · 12-17-2012, 07:54 AM

Well, I would expect T3 to go away when you have the total gland removed. The thyroid makes it. And it does not get much into the blood when you convert it in the tissues.

From what I learned, it is formed right where it is needed only.

I have read that taking your pulse regularly with T3, and also your morning temperature may help reveal if your dose is too low or too high. Increased heart rate is one sign of too much.

Only special compounding pharmacies do this ...and maybe not even many of them, either. You have to find those either online, or call around locally.

This particular topic appears on the net. I'll send you a link to it, in PM.

katycoyote · 05-01-2013, 04:38 PM

I hope you meant dessicated thyroid (pig's thyroid gland.) I finally got on a high enough dose of Armour thyroid that I am much improved.

Quote:

Originally Posted by Joano

This thread is very interesting to me as I am also hypothyroid, and I take .175 mg synthroid everyday and an additional half pill once a week. Two years ago I had emergency gall bladder surgery when a stone became stuck in the duct.

I recently read an article about Dr. Mark Starr's treatment of hypothyroidism, Type 2 (which I'd never heard of beforehand). I have a lot of the symptoms mentioned. He also treats patients with dessicated liver. I don't think my endo would be open to change, however. Dr. Starr has a clinic in Phoenix according to this article which was dated December 2008 and appeared in the "Townsend Letter, The Examiner of Alternative Medicine." I don't remember now what I was researching when I ran across it.

Stacy2012 · 05-02-2013, 05:04 PM

Katycoyote,

If you don't mind me asking, how much are you taking?? I am on a half grain, split into twice a day, of the nature throid. I feel like I need to up my does. My numbers were all within normal ranges but it's been 4 months or more since I did blood work.

Im thinking about checking it again but I know it will be a battle to get my dr to up my dosage.

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