I have been taking Miralax since the first year of my condition for constipation. I take percocet and oxycontin and a few other meds that all add up to constant constipation, so Miralax is the only thing that works. But since I have been taking it from nearly the beginning there has been no recognizable difference in my pn. Perhaps it does help and I don‘t see it. I also used it with my youngest child who was constipated from birth. We used suppositories until she was a toddler and then I used apple juice, or Miralax when there was extreme conditions. She never was dependent on it and now she has grown out of the problem (too long of a colon) finally at age 5 ½. Dr, Smith - thanks for you links and information it I appreciate these tidbits a lot!

I don't think the PEG works orally for PN.... If you check those studies carefully...I would like to see the links in fact...

That PEG was injected into the tissue. And it does not say how much etc.

example:
This is a topical application, not oral.

This one also "applied" to both ends of cut nerves in animals.
http://www.ncbi.nlm.nih.gov/pubmed/22302626

This complicated paper uses a PEG film applied to the
surgical wound area:
http://www.ncbi.nlm.nih.gov/pubmed/20421076

So taking Miralax is not going to provide any nerve healing.
It is not absorbed mostly. The huge molecule is too large.
However in some adults a tiny portion may be absorbed. It seems that children have more of an issue with this problem than adults.

I take it regularly, about a dose and a half daily. When I asked the GI doctor if it was addictive, he laughed in a mean way (he was a mean guy) and said with my problems I was going to be dependent on something or I would never go at all. He was a real bast**d but it was the best advice I ever received. The pain I was in from fissures was much worse than childbirth, and it took about eight months, but the miralax allowed it to finally clear up.
Mine is a hereditary, progressive neuropathy. I have almost no sensation from above the knees down, and am losing muscle control slowly, so if there were improvement it would be offset by deterioration.

Topical would be fine, if it worked. I wasn't thinking of running out and trying anything rash (I don't do rash. ) I was just reading about it, and the neurogenic mentions were intriguing.

Doc

When I mean topical I mean applied to the cut ends of the nerves. Not on the skin.

The newest study made a film scaffold with chitan (which comes from crab shells and is a fiber). The nerves (axons) were severed and the bond applied to facilitate regrowth.

For us PNers...damaged axons....one would have to have location in which to inject the product once it is approved safe.

Not going to be seen for us for a LONG TIME. May however help people with spinal cord trauma from accidents etc..

Hi Susanne,

I'm really liking the Butrans. The first couple of days I was pretty stoned, & I've had a couple of really bad headaches from it. I needed to take some Gravol as I was nauseated as well, but after that initial couple of days it's all been really good. There is a long list of possible side affects, as with any other med.
My pcp just prescribed Motilium & wants me drink some Mag Citrate & some Milk of magnesia. I'll do that tomorrow, so I guess I'll spend my day in the bathroom. I talked to my doc about drinking beer, she said it's okay to have a couple of beer, it will help with my bowel issues. I will cut down though, as when I'm on days off I drink 3 -5 beer a night. I think that's too much.
You should talk to your Dr. about Butrans to see if it's right for you. It's nice cause u just put in on once a week, less pills to remember to pop!!

Hope u feel better.

How can beer help the bowel issues?

If it enables you to pass your stools, I'd be very suspicious that you have gluten issues. Beer of all the alcoholic drinks is filled with gluten. And people who get loose on beer, are showing a potential sign of gluten intolerance.

Gluten intolerance can be a trigger for PN as well!
This excellent website explains:
http://sites.google.com/site/jccglutenfree/
and this is the PN part:

http://sites.google.com/site/jccglut...eralneuropathy

Don't you think there is a better way to get better bowels then the drinking? I have never heard of beer causing bm but even if so it does not sound like a healthy choice. Sorry if I am out of place but just like laxatives cause bowels one should not take them regularly. I know you stated your doctor said it was ok to drink but that is concerning especially since you are on meds and I am surprised he or she would not feel liable if something happened just from that stand point. That has been my fear of drinking which I don't that meds do mix and I don't want other issues. Plus the liver issue which not from alcohol but I did have issues around and it is not pleasant.
Anyhow sorry if I am out place. I hope you take care

Beer is made from grains such as wheat, barley and rye. Grains have fiber and that can help with B.M.'s. There is also gluten free beer for those who cannot tolerate it. A beer or two a day won't harm most people. It is when it's overdone that there may be trouble. Jiggered's doctor should know what can be tolerated.

(ROTFLMAO) Does that sound like one of those TV commercial disclaimers, or what?

Doc