Prediabetic Neuropathy or not?

mrsD · 03-19-2012, 03:14 PM

Solvents can do lots of damage. They can damage bone marrow too. They damage DNA. Did you have any immune globulins tested? IgM, etc.
Benzene for example causes leukemia.
Here is an interesting list of chemicals/solvents and what they can do to the body:
http://www.mcsbeaconofhope.com/42_co...als_and_th.htm

I don't think they hang around unless perhaps in the fat cells.
When you lose weight they may be released. But what solvents do also is defat nerve cells... strip them of the myelin. If the myelin does not regenerate, then the damage is permanent.

NAC can cause rashes and/or skin reactions in some people.
Why don't you stop it for a month or so and see if there is any improvement from that?

Richie Rich · 03-19-2012, 05:41 PM

Yes I had Autoimune Test done that were negative.

From what I gather on searching solvents can cause nerve damage with a delay up to four months not years down the road, and yes they do store in fat cells but I did no lose weight at the time this started and I don't think the body would store all of the original exposesure or release enough at one time many years later to cause this. My impaired glucose tolerance over years could have caused this, I estimate from my current sugar levels after eating that my blood sugar prior to going low carb were spiking to a little over 200 at 1 Hr post meal and returning to normal quickly at 2 Hrs even though my neuro says that would cause nerve damage. I Hope diet and exercise with the supplements will heal my nerves. Maybee my twitching muscles in my legs are a sign of reinervation, I also had those in my hands and arms for a while and those have mostly stopped besides an occasional twitch which I think is normal.

Are there any supplements to help Impaired Glucose Tolerance besides Chromium and R-ALA which I alredy take. I also get on the treadmill 30 min after a meal for 15 min to keep my post meal sugar under 120.

mrsD · 03-19-2012, 05:43 PM

Twitching in muscles can be a sign of low magnesium too.

Really, fixing magnesium affects so many systems. Do you take that or consider that?

Richie Rich · 03-19-2012, 06:27 PM

Yes I am taking a Calcium/magnesium citrate not the useless oxide form. I also believe the doc did include magnesium in my vitamin testing and was at a good level, I have also tried tonic water to no aval. Does high sugar level damage to nerves cause this twitching or is this a sign of reinervation?

mrsD · 03-20-2012, 04:44 AM

Well, blood work for magnesium is not really useful except when showing very very low (which happens on diuretics) or very very high. The in between range is not really indicative of what is going on in the cells. Special tests called intracellular are more accurate.

But twitching also comes when blood sugars are low. I've read on symptom lists that up to 70% of people with LOW blood sugar get twitching. The carnitine should help this some.

I know when I do the long fast for blood work, my left calf always twitches. Try and pay attention to when you get the twitching in relation to food intake. At night? or when you are due to eat?

People with glucose control issues, do lose magnesium in the urine. It is part of the diabetic process that is not understood well.

You might try using 1 or 2 grams of Taurine daily.... this amino acid is recommended for diabetics and will help muscles and nerves both in the brain and periphery.

Taurine is inexpensive and easy to tolerate. It even improves bile flow.
http://en.wikipedia.org/wiki/Taurine

AVR1962 · 04-04-2012, 01:01 AM

Quote:

Originally Posted by Richie Rich

Hi Everyone,

I am a 40 year old male in general good health, Problem started a year and half ago with sensitive skin on lower legs and feet then numbness in big toe and ajascent toe in morning time and cramping burning pain in lower right calf after walking a distance also tingling and numbness in feet and hands at night, after months of this I went to my doctor who did blood testing, everything came back OK except for my A1C which was 6.0 He said this could possibly be the cause and told me what to not eat and what not to eat to get my blood sugar down to normal. I totaly changed my diet to low carbs and got my A1C down to 5.4 after a few months but symtoms persist, I did notice at that time the tingling and numbness at night was alot less. In the middle of this I hurt my back and did physical therapy but still had back pain, I was then sent to a back neurosurgon who said I had a bulging disc at L4-L5 and this could cause problems in the legs so I ended up having a microdiscetomy and after four months my back felt better but it did not help my legs at all. I am now seeing a regular neurologist who says he would have not sent me for back surgery because when he looked at my MRI it was not that bad. After he did an exam and blood test he did not think I had a neuropathy because I did not have any weakness and I did not have any stabbing pains and he did not agree whith my primary doc that said my prediabetes could be the cause, he thinks I have some carpel tunnel syndrom in my hands and feet but still put me on gabapentin and suggested tonic water for the cramping pain.

I have had an EMG NCS and lyme test, heavy metal test and autoimune blood test all OK except for some nerve conduction velocity slowing in my legs the worst was my right peroneal that was 31 ms others where at 38 ms just below the bottom of the normal 41 ms, the Dr doing the test said these slightly low velocities where most likely because of my 6' 3" height and my leg temperature was cool being at 30.0 celcius.

I am concerned now because I am noticing these symptoms in my upper legs and I don't know if this is part of the healing or if it is getting worse. After 8 months of control over my blood glucose I only notice my toes are not as numb as before glucose control and much less of the tingling and numbness at night which I always thought was because of sleeping in a bad position.

Does this sound like prediabetic neuropathy or something else?

Supplements I am Taking.

GLA 160 mg X 6
Vitamin C 500 mg X 6
Acetyl-L-Carnitine 500 mg X 4
CoQ10 100mg
Inositol 650 mg X 2
R-Lipoic Acid 300 mg
Benfotiamine 150 mg
Ginko Bilboa 120 mg
Vitamin E 400 mg

Keep us informed as to what docs find. Your story is much lkike mine and docs have been searching for answers for over a year. I have been on a gluten-free diet for a year now, diagnosed with Celiac. It is my understanding thru research that gluten damage can cause nueropathy and at first I thought that's where is was ll coming from but I kept getting sick. I had an MRI on my back and showed 2 bulging discs, like you L5 & L4. I had 2 proceedures (not surgery) which helped but still lots of pain in the feet....pins & needles between the toes and numbness from the calves down. Was sent to nuerology where they did all kinds of tests and was told that a person has to lose 30% of the nerve connections for it to show on their tests so she considered my case mild. I was then sent to do a 3 hour glucose test and was diagnosed with pre-diabetes.

dyctiostelium · 04-15-2012, 04:14 PM

Quote:

Originally Posted by Richie Rich

Wow thats interesting, but what about others on this forum that have had small fiber neuropathy and prediabetes? Is something else causing this? I have been thinking what else could be causing these symptoms.

Hi, I'm new here: 40 year old female with prediabetes and neuropathy symptoms.

There seem to be some evidence that support a link between diabetic neuropathy and vitamin D deficiency. Pubmed ID: 22050401 (sorry I can´t post links yet

)

Diabet Med. 2012 Jan;29(1):43-9. doi: 10.1111/j.1464-5491.2011.03510.x.

Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes?
Shehab D, Al-Jarallah K, Mojiminiyi OA, Al Mohamedy H, Abdella NA.

Department of Medicine, Faculty of Medicine, Kuwait University Department of Medicine, Mubarak Al-Kabeer Hospital, Kuwait.

Abstract
AIM: Despite recent reports linking vitamin D deficiency with increased risk of diabetes mellitus and complications, there is limited data on patients with diabetic peripheral neuropathy. We aimed to evaluate the incidence and associations of vitamin D deficiency in 210 patients with Type 2 diabetes with and without diabetic peripheral neuropathy.
(...)
RESULTS: Eighty-seven patients had diabetic peripheral neuropathy and these patients had significantly longer duration of diabetes and higher HbA(1c). Age, gender, incidence of retinopathy and coronary heart disease were not significantly different from those without neuropathy. Mean (SD) vitamin D was significantly lower in those with neuropathy [36.9 (39.9) nmol/l] compared with those without [58.32 (58.9) nmol/l] and 81.5% of patients with neuropathy had vitamin D deficiency compared with 60.4% of those without. Vitamin D showed significant (P < 0.05) correlations with total cholesterol, LDL-cholesterol and urine microalbumin:creatinine ratio. Binary logistic regression analysis showed that diabetic peripheral neuropathy was significantly associated with vitamin D deficiency (odds ratio = 3.47; 95% CI = 1.04-11.56, P = 0.043) after inclusion of potential confounders such as duration of diabetes, HbA(1c) and LDL-cholesterol.
CONCLUSION: Vitamin D deficiency is an independent risk factor for diabetic peripheral neuropathy, and further studies are required to confirm if Vitamin D supplementation could prevent or delay the onset.

And there are some early, non-controlled observations on the favorable effects of vitamin D supplements: Pubmed ID 18413561.

Arch Intern Med. 2008 Apr 14;168(7):771-2.
Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain.
Lee P, Chen R.
*edit*

"Vitamin D has been increasingly recognized for its
pleiotropic effect, including improvement in glycemic control.
9 It is also free of adverse effects. Because the treatment
of diabetic neuropathic pain is generally unsatisfying
for patients and is associated with significant adverse
effects, we advocate a trial of vitamin D supplementation
in vitamin D–insufficient patients with neuropathic
pain. It is unlikely to have any harmful effects and
may offer not only pain relief but also beneficial effects
on bone health and glycemic control."

I'm giving it a shot, 2000 UI of vitamin D (VD4, ergocalciferol, from GNC) a day.
I'm been on it for a month and I seem to be better. We'll see.

I'm sharing it in case someone else would find it useful

Best,
Irma

mrsD · 04-15-2012, 04:32 PM

Welcome to Neurotalk:

While some of the findings about low Vit D and PN are really coming to light now, so are the findings that ergocalciferol is not that effective in raising levels:

Please read this:
http://neurotalk.psychcentral.com/post825922-70.html

and this:
http://neurotalk.psychcentral.com/post735110-42.html

I'd be using D3 instead, cholecalciferol.

dyctiostelium · 04-15-2012, 05:10 PM

Quote:

Originally Posted by mrsD

Welcome to Neurotalk:

While some of the findings about low Vit D and PN are really coming to light now, so are the findings that ergocalciferol is not that effective in raising levels
(...)
I'd be using D3 instead, cholecalciferol.

Ah, excellent! Long live forums! The informed hive-mind! We are definitely more than the sum of the parts

I live in Mexico and I'm finding out it is not going to be easy to get cholecalciferol supplements as such: it seems to be only sold as multivitaminns with all kinds of funky stuff added.
But I guess that's what the internet is for, right? I'm thinking of getting D3 gel caps from BTR Group, the ones used in the Heaney et al 2011 paper. Or does the forum has another preferred source?

Thanks a lot, really, mrsD, you seem to be a driving force in here.

I'm now studying the stickies for the rest of the things you guys have personally found that work

mrsD · 04-15-2012, 05:52 PM

I believe that iherb.com may ship to Mexico.

D3 here is really really inexpensive. http://www.iherb.com/info/shipping/International

only one example:
http://www.iherb.com/Now-Foods-Vitam...-Softgels/8229

I don't know what dose you intend to take.

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
paraneoplastic/SF-non lenght dependent neuropathy/demyelinating neuropathy	pelztier86	Peripheral Neuropathy	16	05-21-2013 12:16 PM
Neuropathy	Fran H	Peripheral Neuropathy	5	07-20-2011 06:22 PM
Small Fiber Neuropathy (or Length-Dependent Neuropathy)	plgerrard	PN Tips, Resources, Supplements & Other Treatments	1	05-09-2010 06:56 AM
neuropathy	jackman44	General Health Conditions & Rare Disorders	4	04-25-2010 10:54 AM
does anyone have Mag neuropathy?	kaufmr	Peripheral Neuropathy	0	02-22-2010 01:05 PM

Site Navigation

NeuroTalk Online Support Groups

Prediabetic Neuropathy or not?

NeuroTalk Forums