I just read about Low Dose Naltrexone. Does anyone here have experience with it? I know it's used for MS; is it also good for PN?
Thanks,
Steven

http://painsandiego.com/2011/01/

This explains about glia cells


http://painsandiego.com/tag/allodynia/


Naltrexone is an immune modulator.

The site of action of naltrexone is at the Toll-like receptor (TLR4) attached to the cell surface membrane of glia.

The ability to view activated glia would help greatly in treatment of so many conditions including neuropathic pain.


I was thinking about trying this drug myself but havent seen much on it for nerve pain. I spoke to a doctor who thinks my burning/allodynia is from neuroinflamation. There really isnt many drugs on the market that target this. I was told that in the next few years some may come out as they are in clinical trials.

http://en.wikipedia.org/wiki/Allodynia

I forgot to mention, my issue is with Allodynia and this wiki seems to explain that there are links at a cellular and molecular level.