Could very high levels of B6 cause PN? Things like nerve zaps, random itching, muscle twitching, occasional leg muscle soreness?

If the range is 2.1 - 21.7 and ones blood readings were at 25.7

I started taking the B6 tablet (100 mg per day) and then 3 weeks later I began to experience the PN symptoms. I continued taking the B6 for another 2 weeks (5 weeks total) before I stopped taking it. Took a blood test 2 weeks later after I stopped the B6 tablet and my B6 blood levels were 25.7

So my levels had to be MUCH higher 2 weeks prior to the blood test because I was still on the B6 tablet 2 weeks ago.

1 - Could the high levels B6 have caused my PN symptoms?
2 - How long before my levels will drop?
3 - Is B6 stored in the tissue for longer periods? If so, how long before it's out of the tissue?

Hard to say. According to studies you have to take really high doses for a LONG time and even then only a few people were affected.

Your test is not that high...and reflects your supplement use.
Pyridoxal is stored in muscles for a short time, for energy management.

I wouldn't worry about it.

Here is my B6 thread:
http://neurotalk.psychcentral.com/thread30724.html
Lots of information gathered on that thread.

What did your doctor say? Isn't he the one who told you to take
that dose?

It was the podiatrist who advised me to take B6 for a foot Mortons Neuroma. After taking that dose (100mg) for 3 weeks is when I developed the PN symptoms (random nerve zaps & stings, random itching). These symptoms continued and then I stopped taking the B6 and had a blood test 2 weeks later. That blood test showed the 25.7 and that was 2 weeks worth of not taking B6.

According to my doctor my B6 levels were probably in the 30+ when I was taking the B6 pill. After 2 weeks of not taking the B6 the blood work showed the 25.7. The theory by my doc is that for my levels to be that high (25.7) after not taking it for 2 weeks means most likely that while taking it I was well over 30+ or maybe 40+.

Without knowing what my B6 levels were prior to taking the B6 supplement, it's hard to judge what my levels were. When I was tested 3 weeks ago my B12 levels were 870. After taking Methyl B12 (2-3 times a week at 5,000mg), my levels are now 1,170

Maybe my body just is very efficient in storing B12 and B6 and any additional supplementation builds up really fast and in the case of B6, could it have caused my PN?

I found this on Wiki and it's strange on how different countries have established different levels of B6 toxicity:

http://en.wikipedia.org/wiki/Vitamin_B6


In 1993, the European Community Scientific Committee on Food defined intakes of 50 mg of vitamin B6 per day as harmful and established a tolerable upper intake level of 25 mg/day for adults in 2000.

The Expert Group on Vitamins and Minerals of the Food Standard Agency UK (UK EVM) derived a safe upper level (SUL) of 10 mg/day for a 60-kg adult in 2003.

The tolerable upper limit has been set by the US FDA at 100 mg/day in 2000

Europe view 25mg max per day, the UK says 10mg max per day, the USA goes to 100mg per day.

The European Codex is highly controversial and was fought against mightily by citizens in Europe. It was seen as an attempt by Big Pharma drug companies to keep their drugs more prominent in treatments.

It is far more likely to be low in B6 than high.

Remember ranges were NOT made with people taking any supplement at all. Taking a supplement will naturally throw you out of those "statistical" estimates, which is what they are.

Ranges therefore are best guesses only, and not carved in stone.
If all of them were redone, today, they would probably be very different in fact. Intracellular tests are thought to be more accurate, and measure things INSIDE cells, not just floating around in the serum.