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Old 03-16-2016, 06:26 AM #5
glenntaj glenntaj is offline
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glenntaj glenntaj is offline
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Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
15 yr Member
Default Conditions associated with the variations--

--of the anti-nuclear antibody--specifically, the vasculopathies and connective tissue disorders (this is a very broad group of disorders that includes lupus, polyarteritis, Sjogrens, Bechet's, others) are certainly considered inflammatory conditions, as the autoimmune attacks here are systemic and affect multiple tissue types, though not always the same types--different antibody and cytokine combinations do have preferences for some tissue types over others, in general, which is why the syndromes are at least somewhat distinguishable, thought there are overlaps, and there is "mixed connective tissue disease".--see:

http://neuromuscular.wustl.edu/antib...tml#vasculitis

Of course, these are hardly the only things that cause inflammation in the body--pure old traumatic injury does too (and compression is a type of traumatic injury), as do certain toxins.

In general, anything that alerts the immune system is likely to cause an inflammatory response, though the strength of it varies depending on what pathways are activated.

And, as noted, some autoimmune responses are so specific they may occur without noted rises in the usual inflammatory markers such as C-reactive protein.
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