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Old 09-09-2007, 09:32 PM #20
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Unhappy so...

so you are still using the Indocin?

I really would look to that first.
The use of proton pump inhibitors reduce but do not 100% prevent bleeds.
And Indocin is very aggressive in this regard.

The slight anemia is a warning sign IMO. Use Ocam's Razor in cases like this
first. The most obvious.

Also to consider for the anemia is the failure of iron absorption. Removing acid
from the stomach seriously impairs iron absorption leading to anemia. I have seen this in otherwise healthy males using long term Nexium/Prilosec.

NSAIDs can cause renal damage/failure:
http://www.pdrhealth.com/patient_edu...HG01NP02.shtml
Quote:
Over-the-counter and prescription medications can contribute to CRF. Several drugs cause damage to the kidneys, including ibuprofen(Motrin,, Nuprin, Advil), acetaminophen (Tylenol), indomethacin (Indocin), and the antibiotics Gentamycin (Ed-Mycin, G-Myticin, Garamycin, Gentamar) and sulpha drugs, which are typically used to treat infections. If taken regularly over long periods, these medications act like poisons to the kidneys.
You know I have brought this up many times with you, and I know you need the help the Indocin provides, but its "price" may be too high now for you.
In the private sector and long term sector this drug is only used as a last chance thing. Certain severe headache patients, short term acute gout, etc.
As a matter of fact some companies have stopped making it, and a shortage was in place when I left for vacation.

This just feels toxic to me what you describe, and given what Indocin is and does it should head the list of causative agents.
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