Nope. Been on all of them over 10 years....Tramadol landed me in the ER and cost a CT scan. I was on Zoloft for years, and they kept treating the side effects of that with new drugs. Until they figured out....I couldnt take them.


10% of the Caucasian population can not metabolize SSRI's due to a polymorphism of 2D6. Some people have other cytochromes besides 2D6 that kick in to metabolize. If you notice on the chart, amitriptyline is metabolized by quite a few and inhibits quite a few, as do some of the SSRIs.


My neuro didn't encourage using them. A different doc did. What a waste of money. If that had to come out of my pocket, I would be really mad. I should have been given a free sample. Why not? Do they give free samples of Cymbalta? They give them for everything else. I should have asked and from now on, I am asking for free samples before I waste other premium payers money like that!

If it works for somebody, then fine, however, the SSRIs are tricky drugs. Yes we should be typed for 2D6, but most people are not typed. It seems they prefer the try it and see approach.

At one time I was able to take Welbutrrin and Lexapro, those function a bit differently the -etine drugs.

It seems as this disease process (what ever it really is besides the mystery of idiopathicy) progresses, there is less and less I can tolerate. That makes me a lot more reluctant to experiment. (I didn't go to Woodstock either, but, no I am not conservative.)

I am curious about Rozerum for sleep....anybody taken that? That one is kind of scary, but the commercials are darn cute...I like the groundhog.