regarding Bioperine:
Quote:
Crit Rev Food Sci Nutr. 2007;47(8):735-48.Click here to read Links
Black pepper and its pungent principle-piperine: a review of diverse physiological effects.
Srinivasan K.
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India. ksri.cftri@gmail.com
Black pepper (Piper nigrum) is one of the most widely used among spices. It is valued for its distinct biting quality attributed to the alkaloid, piperine. Black pepper is used not only in human dietaries but also for a variety of other purposes such as medicinal, as a preservative, and in perfumery. Many physiological effects of black pepper, its extracts, or its major active principle, piperine, have been reported in recent decades. Dietary piperine, by favorably stimulating the digestive enzymes of pancreas, enhances the digestive capacity and significantly reduces the gastrointestinal food transit time. Piperine has been demonstrated in in vitro studies to protect against oxidative damage by inhibiting or quenching free radicals and reactive oxygen species. Black pepper or piperine treatment has also been evidenced to lower lipid peroxidation in vivo and beneficially influence cellular thiol status, antioxidant molecules and antioxidant enzymes in a number of experimental situations of oxidative stress. The most far-reaching attribute of piperine has been its inhibitory influence on enzymatic drug biotransforming reactions in the liver. It strongly inhibits hepatic and intestinal aryl hydrocarbon hydroxylase and UDP-glucuronyl transferase. Piperine has been documented to enhance the bioavailability of a number of therapeutic drugs as well as phytochemicals by this very property. Piperine's bioavailability enhancing property is also partly attributed to increased absorption as a result of its effect on the ultrastructure of intestinal brush border. Although initially there were a few controversial reports regarding its safety as a food additive, such evidence has been questionable, and later studies have established the safety of black pepper or its active principle, piperine, in several animal studies. Piperine, while it is non-genotoxic, has in fact been found to possess anti-mutagenic and anti-tumor influences.
PMID: 17987447 [PubMed - indexed for MEDLINE]
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from http://www.ncbi.nlm.nih.gov/pubmed/17987447?ordinalpos=1&itool=EntrezSystem2.PEntrez. Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.P ubmed_Discovery_RA&linkpos=4&log$=relatedreviews&l ogdbfrom=pubmed
There drugs studied so far are Dilantin (phenytoin), Inderal (propranolol) and theophylline (for asthma).
Since not all drugs have yet been studied, care should be taken using Bioperine while taking prescription drugs.
I put up a separate thread here:
http://neurotalk.psychcentral.com/thread92684.html
Until I see otherwise, I'd treat Bioperine like grapefruit juice, which also enhances drug absorption from the GI tract.
This link cautions not to use more than 10mg/day:
Quote:
About Bioperine®
Bioperine is a standardized extract from the fruits of black pepper (Piper nigrum) or long pepper (Piper longum). Its piperine content is 95% or more, compared to only 3-9% found in raw forms of these peppers.
Black pepper extract has been used extensively in Ayurvedic medicine to treat fevers, digestive disorders, urinary difficulties; rheumatism, neuralgia, and boils.
Recent scientific studies have shown that piperine can greatly increase the bioavailability of many other compounds — such as vitamins, minerals, drugs, and herbal substances. For example, in humans the bioavailability of curcumin was increased by a factor of 20 when used with piperine. Piperine improves the absorption of these compounds in the intestine, promotes their retention in cells, and prevents their being metabolized in the liver.
Piperine has also shown promise as an agent for preventing diarrhea, gastric ulcers, stimulating digestive enzymes, suppressing the induction and spread of lung cancer, preventing epileptic convulsions, and stimulating melanin production.
This supplement is usually used at 5-10 mg/dose. It is rapidly absorbed and its effects on bioavailability of other compounds lasts 1-2 hours. Doses higher than 10 mg require careful consideration of potential drug interactions.
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from
http://www.lifelinknet.com/siteResou.../Bioperine.asp
So there is not definitive answer. But this monograph suggests spacing it out to avoid other drugs.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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07-14-2009, 12:26 AM
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