I am been complaining that my vibrating and twitching have been ramping up lately and that its been really bad. Tonight I'm sitting here trying to figure out why. I think I've figured it out. I've been using my compounded cream pretty liberally( informed Dr and pharmacist, both said it was ok to use that much and over a large portion of my body) It has diclofenac and amitriptyline in it. This afternoon was the first time I put it on my chin line and around my mouth then down my throat. The areas I'm putting the cream are freaking out hours later. My face in those areas ( and other creamed areas) are twitching and vibrating like mad, they are also numb and tingly. Will this stop? Anybody heard of this? This is what I was worried about with taking an antidepressant for anxiety and depression, it would make the twitching worse. I'm scared I've worsened my condition. The extra vibrating and twitching really ramped up about 11 hours after application today. The extra vibrating and twitching has been lingering around because I haven't put the cream on in a couple of days ( other than today) in scared IT won't to back to normal