I hope the Amytriptolene(misspell) works, I have read good things about it as far as side effects. It hopefully will take the edge off the pins & needles. If you get tender and burning skin, Epsom Salt Lotion helped me to have sheets on my feet at night. The only marked improvement I saw from supplements was when my B-12 went from 119 to over 1000. I was taking methylated B-12 plus monthly injections. Others are better at the supplements than I but I remember that you CAN take too much B-6 and my Neuro stopped me from supplementing Zinc. Exercising to tolerance is a common thread with most. I have gained strength in my legs but it was IMO not related to the exercise. The old saying used to be "different strokes for different folks" and if you read posts you will see that there is little ryme or reason with PN. The only constant is change so you will have to use trial and error to pick your own way through until you find out who the new you is going to be. Good Luck, Ken in Texas.