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Wisest Elder Ever
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This is a very dangerous drug... you could have a hidden, non-symptomatic
bleed from it. http://www.rxlist.com/cgi/generic/indometh.htm Most doctors are unaware of long term NSAID use and poor healing. It is usually after the 4 week mark that this begins. Since this involves cox-2 cytokines, and this concept is complex, it is not generally known. (remember Vioxx? -- even with warnings, it was misunderstood). example: http://ajs.sagepub.com/cgi/content/abstract/29/6/801 Quote:
http://www.springerlink.com/content/72w112h1mq218451/ I had a CE (continuing ed class) where this was brought up in relation to osteoarthritis treatment long term with NSAIDs. People on long term NSAIDs should try and use a proton pump inhibitor daily. There can be some protection afforded this way, but not 100%. Some studies show benefit in preventing GI bleeds. Indomethacin is the highest bleeding causing NSAID in the whole family.
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