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Old 05-16-2010, 06:40 AM #17
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mrsD mrsD is offline
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There remains some debate as to how baclofen works:

http://www.ncbi.nlm.nih.gov/pubmed/231227

Quote:
ACTIONS

The precise mechanism of action of baclofen is not fully known. Baclofen is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Although baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.
from http://www.rxlist.com/baclofen-drug.htm

also this is interesting:
http://en.wikipedia.org/wiki/Baclofen

Baclofen is not chemically a benzo...but it does behave like one sometimes. In fact there is a guy on the net who claims it will cure alcohol addiction (in very high doses) which seems like a hard way to do it, to me.

I saw this doctor on TV once not too long ago:
http://www.businessweek.com/magazine...8126_mz018.htm
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